In a small study of 30 people who were pregnant and were given bupropion for 12 weeks to help them quit smoking during pregnancy, no differences in birth weight, length, head circumference, or Apgar score (grading system in newborns to define their wellbeing) were seen. Other studies involving over 2,300 pregnancies exposed to bupropion in the first trimester showed no increase in the chance for birth defects.ĭoes taking bupropion in pregnancy increase the chance of other pregnancy-related problems?īased on the studies reviewed, it is not known if bupropion increases the chance for pregnancy-related problems such as preterm delivery (birth before week 37). The design of this study does not allow a conclusion to be drawn. One study has suggested a weak link between use of bupropion in the first trimester and heart defects. Based on the studies reviewed, it is unlikely that using bupropion during pregnancy would increase the chance for birth defects above the background risk. Two studies did not find a higher rate of miscarriage among people who were pregnant and taking bupropion compared to the background chance for miscarriage in the general population.ĭoes taking bupropion increase the chance of birth defects?Įvery pregnancy starts with a 3-5% chance of having a birth defect. Based on the studies reviewed, it is not known if bupropion increases the chance for miscarriage. However, these case reports did not mention fertility problems.ĭoes taking bupropion increase the chance for miscarriage? Two cases of irregular menstrual cycles linked to bupropion use have been reported. Studies have not been done to see if taking bupropion could make it harder to get pregnant. Can it make it harder for me to get pregnant? For more information, see the fact sheet on depression at. Untreated mental illness might also affect a pregnancy. Some people may have a return of their symptoms (relapse) if they stop this medication during pregnancy. It is not known if or how withdrawal might affect a pregnancy. Stopping this medication suddenly can cause some people to have withdrawal symptoms. If you plan to stop this medication, your healthcare provider may suggest that you slowly lower the dose instead of stopping all at once. Your healthcare providers can talk with you about the benefits of treating your condition and the risks of untreated illness during pregnancy. However, it is important to talk with your healthcare providers before making any changes to how you take this medication. Sometimes when people find out they are pregnant, they think about changing how they take their medication, or stopping their medication altogether. Bupropion is also sold under the brand name Zyban® as an aid to quit smoking. It is sold under the brand name Wellbutrin®. This information should not take the place of medical care and advice from your healthcare provider.īupropion is a medication used to treat depression and seasonal affective disorder. This sheet is about exposure to bupropion in pregnancy and while breastfeeding.
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